We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- RFP Announcement: Nonhuman Primate Core Functional Genomics Laboratory for AIDS Vaccine Research and Development RFP NIAID-DAIDS-NIH-AI-2012-142
- Notice of Intent to Publish a Funding Opportunity Announcement (FOA) for Women's Mental Health During Pregnancy and the Postpartum Period (R01)
- Notice of Intent to Publish a Funding Opportunity Announcement (FOA) for Women's Mental Health During Pregnancy and the Postpartum Period (R21)
- Change in NINDS salary caps for the K02, K08 and K23 Career Development Awards
- Notice of NIH Piloting of Procedures for Special Council Review of Research Applications from PD(s)/PI(s) with More than $1.5 Million Total Annual NIH Support