We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases (F31)
- Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases (F32)
- NIMHD Announces Participation in RFA-AG-20-035, "Building Resources for the Basic Biology of Aging in Health Disparities Research (R24 Clinical Trial Not Allowed)"
- Notice of NICHD's participation on PAR-19-326, Reducing Stigma to Improve HIV/AIDS Prevention, Treatment, and Care in Low and Middle-Income Countries (R21 Clinical Trial Optional)
- Notice of Change to Allowable Appendix Materials for RFA-NS-19-038 "The NINDS Human Cell and Data Repository (U24 - Clinical Trial Not Allowed)"